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Catalysts Webinar | Methyltransferases, Understanding and Application

18/02/2021

Catalysis, Methyltransferases, SAM, Environmentally Benign Methylation, Enzymes Cascades, Tetrahydroisoquinolines
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Webinar Information

6th Catalysts Webinar

Methyltransferases, Understanding and Application

The methylation of alcohols or amines is straightforward undergraduate chemistry. Yet at the same time, it is a prime example of everything that is wrong with chemistry. The reagents are toxic and often cancerogeneous, they have to be used in stoichiometric quantities and even in excess. Consequently, methylation is high on the list of reactions for which a catalytic and environmentally benign approach needs to be found. Methyltransferases are enzymes that will enable exactly this. Therefore, in recent year, much research has focussed on the application of methyltransferases. As they need a co-factor also the benign recycling of the co-factor needs to be addressed. In this webinar, all aspects of methylation catalysed by methyltransferases will be addressed by outstanding experts in the field.

Prof. Dr. Ulf Hanefeld
Biocatalysis & Organic Chemistry,
Delft University of Technology,
Delft, The Netherlands

Date: 18 February 2021

Time: 12:00 pm CET

Webinar ID: 827 0224 9385

Webinar Secretariat: [email protected]

Chair: Prof. Dr. Ulf Hanefeld

The following experts will present and talk:

Prof. Dr. Ulf Hanefeld, Delft University of Technology, The Netherlands

In 1993 Ulf Hanefeld received his PhD in Organic Chemistry from the Georg-August-Universität zu Göttingen, having performed the research both with Prof. H. Laatsch (Göttingen) and Prof. H. G. Floss (Seattle). After postdoctoral years with Prof. C. W. Rees (Imperial College London), Prof. J. Staunton (Cambridge) and Prof. J. J. Heijnen and Dr. A. J. J. Straathof (TU Delft), he received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). He rose through the ranks at the Technische Universiteit Delft and his research in Delft focuses on enzymes, their immobilisation and application in organic synthesis. His special interest are enzymes that enable reactions that are chemically difficult or can replace chemcial processes that are particularly environmentally unfriendly, such as the current methylation technology.

Prof. Dr. Jennifer Andexer, University of Freiburg, Germany

Following a diploma in Biology, Jennifer Andexer carried out her doctoral research working on novel hydroxynitrile lyases at the Institute of Molecular Enzyme Technology (University of Duesseldorf/Research Centre Juelich, Germany). In 2008, she moved to the labs of Joe Spencer, Finian Leeper and Peter Leadlay at the University of Cambridge (UK), where she worked on the biosynthetic pathways of different natural products. She has been head of the Chemical Biology group at the Institute of Pharmaceutical Sciences at the University of Freiburg since 2011, and works on the characterisation of cofactor-dependent enzymes, cofactor regeneration systems and cofactor analogues. In 2020, she was appointed Heisenberg Professor for Pharmaceutical and Medicinal Chemistry.

Prof. Dr. Helen Hailes, University College London, UK

Helen received her Ph.D in 1991 at Cambridge under the supervision of Professor Jim Staunton. She pursued post-doctoral work at Cambridge, and then at Imperial College London with Professor Steve Ley and subsequently with Dr David Widdowson. She joined the Department of Chemistry, University College London as a Lecturer in 1994, becoming a Senior Lecturer in 2002, a Reader in 2005, and Professor of Chemical Biology in 2010. Her research is focused on the development of new sustainable chemistry approaches for use in synthesis. Several projects involve the discovery, optimisation and use of biocatalysts in single or multi-step pathways to construct single isomer biologically active molecules. In addition, she is investigating reactions and multi-step synthetic biology cascades in water and other green solvents.

Prof. Dr. Glenn Burley, University of Strathclyde, UK

Glenn A. Burley is Professor of Chemical Biology at the University of Strathclyde. Glenn was awarded a Bachelor of Medicinal Chemistry (Hon. I, 1996) and a PhD in Organic Chemistry (2000) from the University of Wollongong, Australia. After a post-doctoral stay at the Fullerene Science Centre at the University of Sussex (2001-2003), Glenn was awarded an Alexander von Humboldt Fellowship to work with Thomas Carell at the University of Munich (2004-2006). Glenn began his independent career as an EPSRC Advanced Fellow (2007) at the University of Leicester, before moving to Strathclyde in 2011. Research interests of Glenn’s group focuses on nucleosides and nucleic acids and their application as tools for biocatalysis and to probe gene expresison.

Program

Speaker/Presentation

Time in CET

Prof. Dr. Ulf Hanefeld

Chair Introduction

12:00 – 12:05 pm

Prof. Dr. Jennifer Andexer

Integration of Methyltransferases in Cofactor Supply Cascades

12:05 – 12:40 pm

(with Q&A)

Prof. Dr. Helen Hailes

The Strategic Diversification of Bioactive Tetrahydroisoquinolines Using Methyltransferases

12:40 – 1:15 pm

(with Q&A)

Prof. Dr. Glenn Burley

Cofactor Profiling as a Tool for Regiospecific Enzymatic C-Methylation

1:15 – 1:50 pm

(with Q&A)

Closing of Webinar
Prof. Dr. Ulf Hanefeld

1:50 – 1:55 pm

Webinar Content

On Thursday, 18 February 2021, MDPI and the Journal Catalysts organized the 6th webinar on Catalysts, entitled "Methyltransferases, Understanding and Application".

The introduction was held by the chair of the webinar, Prof. Dr. Ulf Hanefeld, a Full Professor at the Delft University of Technology. His research in Delft focuses on enzymes, their immobilisation and application in organic synthesis. His special interests are enzymes that enable reactions that are chemically difficult or can replace chemical processes that are particularly environmentally unfriendly, such as the current methylation technology.

Prof. Dr. Jennifer Andexer held the first presentation, which was entitled "Integration of Methyltransferases in Cofactor Supply Cascades". She has been head of the Chemical Biology group at the Institute of Pharmaceutical Sciences at the University of Freiburg since 2011, and works on the characterisation of cofactor-dependent enzymes, cofactor regeneration systems and cofactor analogues. In 2020, she was appointed Heisenberg Professor for Pharmaceutical and Medicinal Chemistry.

The second presentation with the title "The Strategic Diversification of Bioactive Tetrahydroisoquinolines Using Methyltransferases" was held by Prof. Dr. Helen Hailes. Her research is focused on the development of new sustainable chemistry approaches for use in synthesis. Several projects involve the discovery, optimisation and use of biocatalysts in single or multi-step pathways to construct single isomer biologically active molecules. In addition, she is investigating reactions and multi-step synthetic biology cascades in water and other green solvents.

The third speaker of the webinar was Prof. Dr. Glenn Burley. His presentation was entitled "Cofactor Profiling as a Tool for Regiospecific Enzymatic C-Methylation". Glenn A. Burley is Professor of Chemical Biology at the University of Strathclyde. He began his independent career as an EPSRC Advanced Fellow (2007) at the University of Leicester, before moving to Strathclyde in 2011. Research interests of Glenn’s group focuses on nucleosides and nucleic acids and their application as tools for biocatalysis and to probe gene expresison.

Each presentation was followed by a short Q&A, moderated by the chair. The webinar was offered via Zoom and required registration to attend. For this webinar, there is no recording available on Sciforum. In order to stay updated on the next webinars on Catalysts, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.

Relevant Special Issues

Biotransformation Catalyzed by Immobilized Enzyme
Guest Editors: Prof. Dr. Ulf Hanefeld, Dr. Yann P. Guiavarc'h
Deadline for manuscript submissions: 31 July 2021

Biocatalytic Resolution of Chiral Molecules
Guest Editors: Prof. Dr. Jaime Escalante, Prof. Dr. Harald Gröger, Prof. Dr. Eusebio Juaristi
Deadline for manuscript submissions: 30 June 2021

Nucleic Acid Modifying Enzymes
Guest Editor: Prof. Dr. David Hornby
Deadline for manuscript submissions: 15 May 2021

Promising Industrial Enzyme
Guest Editors: Prof. Dr. Francisco Valero, Dr. Marina Guillén Montalbán
Deadline for manuscript submissions: 30 November 2021

The Role of Enzymes in the Production of Biofunctional Foods and Food Additives
Guest Editors: Prof. Dr. Emmanuel M. Papamichael, Dr. Panagiota-Yiolanda Stergiou
Deadline for manuscript submissions: 31 July 2021

Bioprocess Engineering and Enzyme Application
Guest Editors: Dr. Scott A. Walper, Dr. Gregory A. Ellis
Deadline for manuscript submissions: 31 March 2021

Enzyme Engineering: From Chemically Induced Modifications to Genetic Code Expansion
Guest Editors: Dr. Jean Bertoldo, Prof. Dr. Hernán Terenzi
Deadline for manuscript submissions: 30 June 2021

Biocatalysis for Tasty Food
Guest Editors: Dr. Cinzia Calvio, Dr. Carlo F Morelli
Deadline for manuscript submissions: 15 September 2021

Enzymes and Biocatalysis
Guest Editors: Assoc. Prof. Dr. Chia-Hung Kuo, Prof. Dr. Chun-Yung Huang, Prof. Dr. Chwen-Jen Shieh, Prof. Dr. Cheng-Di Dong
Deadline for manuscript submissions: 31 October 2021

Biocatalysts and Their Environmental Applications
Guest Editors: Prof. Dr. Baiyu Zhang, Dr. Bo Liu
Deadline for manuscript submissions: 31 May 2021

Chemopreventive Effects of Dietary Natural Products on Modulation of Xenobiotic-Metabolizing Enzymes
Guest Editor: Prof. Dr. Hsien-Tsung Yao
Deadline for manuscript submissions: 30 June 2021

Enzyme Catalysis, Biotransformation and Bioeconomy
Guest Editors: Dr. Edinson Yara-Varón, Prof. Dr. Ramon Canela-Garayoa
Deadline for manuscript submissions: 30 September 2021

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